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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 6
1992 7
1993 9
1994 8
1995 9
1996 20
1997 11
1998 25
1999 34
2000 43
2001 69
2002 84
2003 145
2004 251
2005 368
2006 481
2007 602
2008 724
2009 932
2010 1157
2011 1289
2012 1473
2013 1802
2014 1809
2015 1918
2016 1782
2017 1834
2018 1838
2019 1920
2020 1844
2021 1779
2022 1438
2023 1238
2024 456

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23,956 results

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Page 1
Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle.
Ham DJ, Börsch A, Chojnowska K, Lin S, Leuchtmann AB, Ham AS, Thürkauf M, Delezie J, Furrer R, Burri D, Sinnreich M, Handschin C, Tintignac LA, Zavolan M, Mittal N, Rüegg MA. Ham DJ, et al. Nat Commun. 2022 Apr 19;13(1):2025. doi: 10.1038/s41467-022-29714-6. Nat Commun. 2022. PMID: 35440545 Free PMC article.
Calorie restriction (CR) potently extends health and lifespan, but is largely unachievable in humans, making "CR mimetics" of great interest. CR targets nutrient-sensing pathways centering on mTORC1. ...Therefore, we tested whether rapamycin acts via similar …
Calorie restriction (CR) potently extends health and lifespan, but is largely unachievable in humans, making "CR mimetics" of great i …
Targeting immunometabolism as an anti-inflammatory strategy.
Pålsson-McDermott EM, O'Neill LAJ. Pålsson-McDermott EM, et al. Cell Res. 2020 Apr;30(4):300-314. doi: 10.1038/s41422-020-0291-z. Epub 2020 Mar 4. Cell Res. 2020. PMID: 32132672 Free PMC article. Review.
Evidence is emerging for the targeting of specific metabolic events as a strategy to limit inflammation in different contexts. Here we discuss these recent developments and speculate on the prospect of targeting immunometabolism in the effort to develop novel anti-i …
Evidence is emerging for the targeting of specific metabolic events as a strategy to limit inflammation in different contexts. Here w …
Mechanistic target of rapamycin signaling in mouse models of accelerated aging.
Lee JY, Kennedy BK, Liao CY. Lee JY, et al. J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):64-72. doi: 10.1093/gerona/glz059. J Gerontol A Biol Sci Med Sci. 2020. PMID: 30900725 Free PMC article. Review.
The mechanistic target of rapamycin (mTOR) is an essential nutrient-sensing kinase that integrates and regulates a number of fundamental cellular processes required for cell growth, cell motility, translation, metabolism, and autophagy. mTOR signaling has been impli …
The mechanistic target of rapamycin (mTOR) is an essential nutrient-sensing kinase that integrates and regulates a number of f …
Mechanistic target of rapamycin (mTOR) signaling in status epilepticus.
Crino PB. Crino PB. Epilepsy Behav. 2019 Dec;101(Pt B):106550. doi: 10.1016/j.yebeh.2019.106550. Epub 2019 Nov 13. Epilepsy Behav. 2019. PMID: 31732331 Review.
The mechanistic target of rapamycin (mTOR) pathway plays a critical role in brain development, neuronal shape and size, and synaptic plasticity, as well as learning and memory. ...A growing body of preclinical evidence in in vitro and rodent model systems suggests t …
The mechanistic target of rapamycin (mTOR) pathway plays a critical role in brain development, neuronal shape and size, and sy …
Clinical pharmacokinetics of everolimus.
Kirchner GI, Meier-Wiedenbach I, Manns MP. Kirchner GI, et al. Clin Pharmacokinet. 2004;43(2):83-95. doi: 10.2165/00003088-200443020-00002. Clin Pharmacokinet. 2004. PMID: 14748618 Review.
Everolimus is an immunosuppressive macrolide bearing a stable 2-hydroxyethyl chain substitution at position 40 on the sirolimus (rapamycin) structure. Everolimus, which has greater polarity than sirolimus, was developed in an attempt to improve the pharmacoki …
Everolimus is an immunosuppressive macrolide bearing a stable 2-hydroxyethyl chain substitution at position 40 on the sirolimus (r …
The Role of Rapamycin in Healthspan Extension via the Delay of Organ Aging.
Zhang Y, Zhang J, Wang S. Zhang Y, et al. Ageing Res Rev. 2021 Sep;70:101376. doi: 10.1016/j.arr.2021.101376. Epub 2021 Jun 2. Ageing Res Rev. 2021. PMID: 34089901 Review.
Currently, some drugs can improve quality of life. The activation of mammalian target of rapamycin (mTOR) signaling is one of the core and detrimental mechanisms related to aging; rapamycin can reduce the rate of aging, improve age-related diseases by inhibit …
Currently, some drugs can improve quality of life. The activation of mammalian target of rapamycin (mTOR) signaling is one of …
Unbiased evaluation of rapamycin's specificity as an mTOR inhibitor.
Artoni F, Grützmacher N, Demetriades C. Artoni F, et al. Aging Cell. 2023 Aug;22(8):e13888. doi: 10.1111/acel.13888. Epub 2023 May 24. Aging Cell. 2023. PMID: 37222020 Free PMC article.
Although rapamycin is widely perceived as an allosteric inhibitor of mTOR (mechanistic target of rapamycin), the master regulator of cellular and organismal physiology, its specificity has not been thoroughly evaluated so far. ...Overall, this study provides …
Although rapamycin is widely perceived as an allosteric inhibitor of mTOR (mechanistic target of rapamycin), the master …
Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island.
Arriola Apelo SI, Lamming DW. Arriola Apelo SI, et al. J Gerontol A Biol Sci Med Sci. 2016 Jul;71(7):841-9. doi: 10.1093/gerona/glw090. Epub 2016 May 21. J Gerontol A Biol Sci Med Sci. 2016. PMID: 27208895 Free PMC article. Review.
Rapamycin (sirolimus) is a macrolide immunosuppressant that inhibits the mechanistic target of rapamycin (mTOR) protein kinase and extends lifespan in model organisms including mice. ...Over the past decade, it has become clear that although genetic an …
Rapamycin (sirolimus) is a macrolide immunosuppressant that inhibits the mechanistic target of rapamycin (mTOR) …
Mammalian target of rapamycin.
Meric-Bernstam F, Mills GB. Meric-Bernstam F, et al. Semin Oncol. 2004 Dec;31(6 Suppl 16):10-7; discussion 33. doi: 10.1053/j.seminoncol.2004.10.013. Semin Oncol. 2004. PMID: 15799239 Review.
Targeted molecular therapeutics are tailored toward the genetic abnormalities that cause tumor progression. ...In addition, intermediary markers and/or molecular imaging techniques must be used to identify the biologically relevant dose that is sufficient to inhibit the …
Targeted molecular therapeutics are tailored toward the genetic abnormalities that cause tumor progression. ...In addition, intermedi …
23,956 results
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